Table A1.
Diagnostic, Laboratory, and Procedure Codes Used to Develop the Algorithm to Measure Toxicity of Breast Cancer Chemotherapy During Active Treatment
| Toxicity Condition | ICD9 Codes | CPT Codes, Laboratory Values, Drugs | ||||
|---|---|---|---|---|---|---|
| Infection, fever | 009.0 | 009.1 | 009.2 | 027.0 | 027.1 | |
| 027.2 | 035 | 038 | 039 | 040 | ||
| 041 | 112 | 114 | 115 | 116 | ||
| 117 | 118 | 130 | 320 | 321 | ||
| 322 | 323 | 480 | 481 | 482 | ||
| 483 | 484 | 485 | 486 | 487 | ||
| 488 | 510 | 511.0 | 511.1 | 511.8 | ||
| 511.9 | 513 | 528.01 | 590.1 | 590.10 | ||
| 590.11 | 590.2 | 590.3 | 595.0 | 682.0 | ||
| 682.1 | 682.3 | 682.4 | 682.5 | 682.6 | ||
| 682.7 | 682.8 | 682.9 | 686 | 785.52 | ||
| 780.6 | 780.61 | |||||
| Diarrhea and dehydration | 276.50 | 276.51 | 276.52 | 780.2 | 458.8 | CPT codes: 96360, 96365 |
| 787.91 | ||||||
| Hematologic | ||||||
| Anemia | 284.89-.9 | 280 | 285.3 | 285.9 | 458.8 | Drugs: epoetin, darbepoetin, erythropoietin |
| Laboratory values: hemoglogin < 8.0 | ||||||
| Neutropenia | 288.00 | 288.03 | 288.09 | 288.5 | 288.50 | Drugs: filgrastim, neupogen |
| 288.51 | 288.59 | Laboratory values: ANC < 1.0, GRAN < 1.0 | ||||
| Laboratory values: ALC < 200/μL; < 0.2 ×109/L | ||||||
| Laboratory values: total WBC < 2 × 109/L | ||||||
| Thrombocyopenia | 287.4 | 287.5 | Laboratory values: PLT < 50,000/μL; < 50.0 × 109/L | |||
| Transfusion | 99.0 | 99.04 | 999.89 | CPT codes: 36430, 36511, 85014 | ||
| Leukocytosis | 288.6 | Laboratory values: WBC > 100,000/μL | ||||
| Delirium/transient altered mental states* | 780.93 | 780.97 | 292.2 | 292.81 | 293 | |
| 294.9 | 331.83 | |||||
| Cardiac (includes embolism/thrombosis, syncope, CHF, MI, arrhythmias) | 410 | 415.1 | 427.2 | 427.81 | 428 | CPT code: 33545 |
| 506.1 | 451.0 | 453.0-.8 | 785.0 | 780.2 | ||
| 782.3 | 451.1 | 451.2 | ||||
| Neuropathy | 478.11 | 538 | 616.81 | 528 | 356 | Duloxetine hydrochloride, gabapentin, topiramate, amitriptyline, lamotrigine |
| Severe mucositis | 478.11 | 538 | 616.81 | 528.00 | 528.01 | |
| Liver failure* | 570 | 782.4 | ||||
| Renal failure* | 584 | Laboratory values: creatinine > 3.0 | ||||
Abbreviations: ANC, absolute neutrophil count; CHF, congestive heart failure; CPT, Current Procedural Terminology; GRAN, granulocytes; ICD9, International Classification of Diseases, Ninth Edition; MI, myocardial infarction; PLT, platelets.
*
Not included in final algorithm because of low event rate.