Table 4.
Tests of association by tumor HPV status.
| SNP number/SNP ID¶/gene location |
Genotype | Controls (N = 588) N (%) |
HPV+ HNSCC cases (N = 37) N (%) |
Adjusted OR (95% CI)† |
HPV– HNSCC cases (N = 91) N (%) |
Adjusted OR (95% CI)† |
|---|---|---|---|---|---|---|
| 8 | GG | 414 (74.6) | 28 (77.8) | Ref | 72 (80.9) | Ref |
| rs17586365 | GA | 130 (23.4) | 7 (19.4) | 0.82 (0.34–1.99) | 16 (18.0) | 0.72 (0.39–1.32) |
| Intron 1 | AA | 11 (2.0) | 1 (2.8) | 1.46 (0.17–12.65) | 1 (1.1) | 0.61 (0.07–5.03) |
| GA/AA | 141 (25.4) | 8 (22.2) | 0.87 (0.38–2.02) | 17 (19.1) | 0.71 (0.39–1.28) | |
| 13 | AA | 292 (49.7) | 17 (45.9) | Ref | 40 (44.0) | Ref |
| rs12535536 | AG | 249 (42.3) | 16 (43.2) | 1.21 (0.58–2.49) | 40(44.0) | 1.20 (0.73–1.98) |
| Intron 1 | GG | 47 (8.0) | 4 (10.8) | 0.89 (0.58–6.14) | 11 (12.1) | 1.71 (0.78–3.75) |
| AG/GG | 296 (50.3) | 20 (54.1) | 1.30 (0.65–2.59) | 51 (56.0) | 1.29 (0.80–2.06) | |
| 36 | TT | 138 (23.5) | 6 (16.2) | Ref | 29 (31.9) | Ref |
| rs2072454‖ | TC | 305 (51.9) | 21 (56.8) | 1.71 (0.66–4.43) | 45 (49.5) | 0.55 (0.32–0.96) |
| Exon 4 | CC | 145 (24.7) | 10 (27.0) | 1.59 (0.55–4.61) | 17 (18.7) | 0.46 (0.23–0.91) |
| Asn158Asn | TC/CC | 450 (76.5) | 31 (83.8) | 1.67 (0.67–4.17) | 62 (68.1) | 0.52 (0.31–0.86) |
| 37 | TT | 140 (23.8) | 6 (16.2) | Ref | 30 (33.0) | Ref |
| rs2075110‖ | TC | 306 (52.0) | 21 (56.8) | 1.72 (0.67–4.47) | 44 (48.4) | 0.54 (0.31–0.92) |
| Intron 5 | CC | 142 (24.1) | 10 (27.0) | 1.61 (0.56–4.67) | 17 (18.7) | 0.47 (0.24–0.92) |
| TC/CC | 448 (76.2) | 31 (83.8) | 1.69 (0.68–4.22) | 61 (67.0) | 0.51 (0.31–0.86) | |
| 44 | TT | 495 (84.2) | 22 (59.5) | Ref | 79 (86.8) | Ref |
| rs12538371 | TC | 88 (15.0) | 15 (40.5) | 4.19 (2.02–8.73) | 11 (12.1) | 0.71 (0.35–1.45) |
| Intron 15 | CC | 5 (0.9) | 0 (0.0) | - | 1 (1.1) | 1.04 (0.11–9.77) |
| TC/CC | 93 (15.8) | 15 (40.5) | 4.01 (1.93–8.32) | 12 (13.2) | 0.73 (0.37–1.45) | |
| 51 | TT | 362 (61.9) | 21 (56.8) | Ref | 47 (51.6) | Ref |
| rs845561 | TC | 201 (34.4) | 13 (35.1) | 0.99 (0.48–2.09) | 40 (44.0) | 1.48 (0.90–2.40) |
| Intron 20 | CC | 22 (3.8) | 3 (8.1) | 3.09 (0.81–11.81) | 4 (4.4) | 1.68 (0.51–5.55) |
| TC/CC | 223 (38.1) | 16 (43.2) | 1.15 (0.58–2.31) | 44 (48.4) | 1.49 (0.93–2.40) | |
| 55 | GG | 205 (34.9) | 22 (59.5) | Ref | 32 (35.2) | Ref |
| rs6970262 | GA | 294 (50.0) | 13 (35.1) | 0.48 (0.23–0.99) | 41 (45.1) | 1.02 (0.60–1.79) |
| Intron 21 | AA | 89 (15.1) | 2 (5.4) | 0.21 (0.05–0.93) | 18 (19.8) | 1.63 (0.83–3.19) |
| GA/AA | 383 (65.1) | 15 (40.5) | 0.41 (0.20–0.82) | 59 (64.8) | 1.16 (0.70–1.90) |
†
Adjusted for sex, age, packyear category, drinkyear category and packyear–drinkyear category interaction.
‖
rs2072454 and rs2075110 LD CEU HapMap r2 = 1.00; LD among controls r2 = 0.98.
¶
LD r2 provided if r2 ≥ 0.5.