Table 1.
Innate and adaptive immunity gene transcripts increased at 48 hours in Chlamydia pneumoniae (Cpn)-infected THP1 cells
| Gene symbol | Gene name | |
|---|---|---|
| Inflammatory response | IL1F5 | Interleukin 1 family, member 5 (delta) |
| IL1F8 | Interleukin 1 family, member 8 (eta) | |
| IL1RN | Interleukin 1 receptor antagonist | |
| IRAK2 | Interleukin 1 receptor associated kinase 2 | |
| NLRC4 | NLR family, CARD domain containing 4 | |
| TLR8 | Toll-like receptor 8 | |
| TNF | Tumor necrosis factor (TNF superfamily, member 2) | |
| Host defense against bacteria | DEFB4 | Defensin, beta 4 |
| DMBT1 | Deleted in malignant brain tumors 1 | |
| NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | |
| PTAFR | Platelet-activating factor receptor | |
| Antibacterial response | COLEC12 | Collection sub-family member 12 |
| CYBB | Cytochrome B-245, beta polypeptide | |
| Cytokines, chemokines, and their receptors | CCL2 | Chemokine (C-C motif) ligand 2 |
| IFNB1 | Interferon, beta 1, fibroblast | |
| IL6 | Interleukin 6 (Interferon, beta 2) | |
| Septic shock | SERPINA1 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Transcripts analyzed included those associated with the host response to pathogens, including inflammatory response genes, antibacterial humoral response genes, cytokines, chemokines and their receptors, genes involved in bacterial host defense mechanisms and septic shock.