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. 2015 Jan 15;5:290. doi: 10.3389/fphar.2014.00290

Figure 4.

Figure 4

sEH gene deletion reduces infarct size 72 h after MCAO in RS female mice. Three days after MCAO, infarct size was measured via TTC stain in young and reproductively senescent (RS) WT and sEHKO mice (A,B) and WT mice treated with vehicle or the sEH inhibitor t-AUCB (C,D). (A) Representative infarct sizes in WT and sEHKO mice. (B) Infarct size was not altered by age in WT mice or by sEH gene deletion in young mice. In RS mice, infarct size was decreased in the cortex and total hemisphere of sEHKO mice compared to WT mice (*p < 0.05). (C) Representative infarct sizes in vehicle and t-AUCB treated mice. (D) Infarct size was not altered by age in vehicle-treated WT mice or by sEH inhibition in young mice. In RS mice, sEH inhibition decreased infarct size in both the cortex and total hemisphere compared to young vehicle-treated mice, but not compared to RS vehicle-treated mice (*p < 0.05). N = 9–15 per group.