Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 15;5:798. doi: 10.3389/fmicb.2014.00798

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 van Staalduinen and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

2-oxoglutarate oxygenase catalyzed hydroxylation and their biochemical effects. (A) Hydroxylation of proline residues of collagen by procollagen prolyl 4-hydroxylation (P4H) and prolyl 3-hydroxylase (P3H) increase the structural stability of collagen. (B) Hydroxylation of collagen lysine residues by procollagen lysine 5-hydroxylase (PLOD) provides further stability through creating cross-linking sites. (C) Hydroxylation of HIF proline residues by prolyl hydroxylase domain (PHD) enzymes stabilizes the interaction between HIF and von Hippel Lindau (VHL) protein targeting HIF for degradation, while asparaginyl hydroxylation of HIF by factor inhibiting HIF (FIH) acts to inhibit transcriptional activity by disrupting the interaction of HIF with p300. Both hydroxylation events result in suppression of the hypoxic response. (D) Lysyl hydroxylation of a variety of proteins by hydroxylase Jmjd6 has effects on alternative splicing (U2AF65), epigenetic regulation (histones H2A/H2B and H3/H4), and p53 tumor suppressor activity.