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. 2015 Jan 15;5:679. doi: 10.3389/fimmu.2014.00679

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Copyright © 2015 De Libero, Lau and Mori.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cladogram and schematic diagram of human BTN and BTNL family members. Protein sequences were aligned with ClustalW2 and the tree rendered using FigTree software (tree.bio.ed.ac.uk/software/figtree). Diagram shows the domain organization of members belonging to the BTN family consisting of two extracellular Ig-like domains, IgV and IgC, a single-pass transmembrane domain (TM) and an intracellular B30.2 domain. Exceptions include BTN1A1, consisting of a short IgV-like domain; BTN3A2, lacking a B30.2 domain; BTNL9, containing a single Ig-like domain; and BTNL2, consisting of four extracellular Ig-like domains and lacking a B30.2 domain.