Table 1.
Antigens stimulating γδ cells.
| γδ TCR/cell type | Antigens/restriction molecules | Reference |
|---|---|---|
| HUMAN | ||
| Vγ (several) Vδ1 | MICA, MICB | (3, 22) |
| Vγ (several) Vδ1 | CD1c, CD1d | (12 –17) |
| Vγ4Vδ5 | EPCR | (18) |
| Vγ9Vδ2 | F1 ATPase, Apo A-I | (23) |
| Vγ9Vδ2 | GroEL homolog on Daudi Burkitt’s lymphoma cells | (25) |
| Vγ9Vδ2 | Hsp60, Hsp65 | (24, 26, 27) |
| Vγ9Vδ2 | IPP, HMBPP | (43 –45) |
| Tetanus toxoid | (30, 31) | |
| DXS2 or Rv2272 peptides | (40) | |
| Vδ1 clones | HLA-A24, HLA-A2 | (9, 10) |
| Vγ4Vδ1 | HLA-B27 | (32) |
| Vγ3Vδ2 | Histidyl-tRNA synthetase | (39) |
| MOUSE | ||
| Hybridoma G8 | T10, T22, T27 | (5, 11, 21) |
| Hybridoma KN6 | T27 | (11, 19) |
| Hybridoma LBK5 | IEk | (11) |
| Vγ1Vδ8 (NX6) | Cy3 | (41) |
| Vγ4Vδ4 (1G9) | NP | (41) |
| Vγ1–Jγ4/Vδ5 (MA2) | PE | (42) |
Apo A-I, apolipoprotein A-I; CD1c or CD1d, cluster of differentiation 1 isoforms; Cy3, cyanine 3; DXS2, mycobacterium 1-deoxy-d-xylulose-5-phosphate-synthase 2; EPCR, endothelial protein C receptor; HLA, human leukocyte antigen; HMBPP, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate; Hsp, heat-shock protein; IPP, isopentenyl pyrophosphate; MICA or MICB, MHC class I chain-related protein A or B; NP, 4-hydroxy-3-nitrophenylacetyl; Rv2272, mycobacterium transmembrane protein; T10, T22, or T27, MHC class Ib proteins; PE, algae protein phycoerythrin.