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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: Annu Rev Virol. 2014 Nov 1;1:261–283. doi: 10.1146/annurev-virology-031413-085537

Figure 1.

Figure 1

The immunity-related IFITM genes (IFITM1, IFITM2, and IFITM3), together with the osteoblast-restricted IFITM5, form a gene cluster in humans that is conserved in mice and chickens (25, 26). Alternative gene names are given in parentheses. Exons are depicted in color and introns in dark gray. Arrows indicate the direction of transcription. Mice possess two additional immunity-related Ifitm genes, Ifitm6 and Ifitm7 (19). Ifitm6 lies within the chromosome 7 Ifitm cluster, but Ifitm7 is a retrogene located on chromosome 16. IFITM10, a gene of unknown function, lies outside the IFITM cluster but remains on the same chromosome (25).