TABLE II. 5α-Reductase-3 Immunostaining in Malignant Human Tissues.
| Tissue | Number of positive cases/ total cases |
Staining intensity |
|---|---|---|
| Adrenal Pheochromocytoma | 1/2 | −/+ |
| Bladder | ||
| Low grade TCC | 0/2 | − |
| High grade TCC | 2/2 | + |
| Small Cell CA | 2/2 | − |
| Breast | ||
| Lobular CA | 2/2 | + |
| Metaplastic CA | 2/2 | + |
| Colon Adeno CA | 2/2 | ++ |
| Esophagus Adeno CA | 2/2 | +/++ |
| Kidney | ||
| Chromophobe CA | 4/4 | +++ |
| Papillary CA | 1/2 | ++ |
| Renal Clear Cell CA | 2/2 | ++ |
| Liver HCC | 2/2 | ++/+++ |
| Lung | ||
| Adeno CA | 2/2 | ++ |
| Mesothelioma | 2/2 | − |
| Leiomyosarcoma | 2/2 | − |
| Ovary | ||
| Mucinous CA | 4/4 | +/++ |
| Serous CA | 0/2 | − |
| Stomach Adeno CA | 2/2 | ++/+++ |
| Testis | ||
| Seminoma | 2/2 | ++ |
| Embryonal CA | 2/2 | + |
| Yolk Sac CA | 1/2 | ++ |
| Thyroid | ||
| Papillary CA | 4/4 | +++ |
| Medullary CA | 2/2 | + |
| Uterus Endometroid CA | 2/2 | ++ |
Criteria for immunohistochemical analysis: −, negative staining; +, weak staining; ++, moderate staining; +++, intense staining; TCC, transitional cell carcinoma; CA, carcinoma; HCC, hepatocellular carcinoma.