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. 2014 Dec 6;13:480. doi: 10.1186/1475-2875-13-480

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© Ho et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Anti-PfHRP2 antibody impairs the ability of three PfHRP2-detecting RDTs to detect cultured P. falciparum . Three brands of RDT (SD, ICT and First Response) were tested with P. falciparum-parasitized red cells pre-incubated with normal plasma (NP) or plasma from a subject with high titre anti-PfHRP2 antibody level (S14). Blood was serially diluted using normal human blood maintaining a 50% haematocrit to parasite densities of 100,000, 30,000, 10,000, 3,000, 1,000, 300, 100, and 30 parasites/μL (1–8). The experiment was undertaken before (A) and after (B) the blood was washed to remove any residual PfHRP2 present in the culture medium.