Table 1.

Characteristics of the 756 POPS participants by HPV16 L1 serostatus in unadjusted and adjusted modeling

Characteristics of POPS participants		% HPV16 L1 Seropositive#	HPV16 L1 Serology~
	n=756	n=167	Unadjusted (PR)	Adjusted (PR)^
Age
Younger than 45	217	27%	REF	REF
45–55	318	21%	0.79 (0.58–1.1)	0.81 (0.59–1.1)
55 or older	220	20%	0.76 (0.54–1.1)	0.78 (0.54–1.1)
continuous p-trend			0.42	0.62
Gender
Female (WIHS)	387	21%#	REF	REF
Male (MACS)	369	24%#	1.1 (0.87–1.5)	1.2 (0.71–2.0)
p-value			0.34	0.53
Cigarette Smoker
Never	241	28%	REF	REF
Former	211	18%	0.65 (0.46–0.91)	0.67 (0.47–0.95)
Current	297	20%	0.69 (0.51–0.94)	0.68 (0.48–0.97)
p-value			0.01	0.03
Recent* oral sex partners
0	403	18%	REF	REF
1	165	25%	1.4 (0.99–2.0)	1.4 (0.97–2.0)
2 or more	179	30%	1.7 (1.2–2.3)	1.7 (1.1–2.5)
p-trend			0.001	0.01
Lifetime number of oral sex partners
0–4	260	20%	REF	REF
5 to 99	307	22%	1.1 (0.80–1.5)	1.0 (0.71–1.4)
100 or more	176	26%	1.3 (0.90–1.8)	1.0 (0.60–1.6)
p-trend			0.18	0.91
HIV-infection
No	293	20%	REF	REF
Yes	463	24%	1.2 (0.90–1.6)	1.4 (1.0–1.9)
p-value			0.23	0.02
HIV-status + CD4 T cell count
Negative	293	20%	REF	REF
Positive CD4>500 cells/µL	253	24%	1.2 (0.87–1.6)	1.3 (0.97–1.9)
Positive CD4 200–499 cells/µL	169	22%	1.1 (0.77–1.6)	1.4 (0.95–2.0)
Positive CD4<200 cells/µL	38	32%	1.6 (0.95–2.7)	2.2 (1.3–3.8)
CD4 p-trend in HIV-positives			0.53	0.22

^{^}Adjusted for age, gender, smoking status, number of recent and lifetime oral sex partners, HIV/CD4 status, study site, alcohol use, and frequency of recent toothbrushing

^*Recent defined as within the last six months

^~Risk factors for HPV16 L1 seropositivity were calculated with Possion Regression with robust variance

^#Optical density (OD) of seropositive individuals was similar across risk factors, except HPV16 seropositive women had a higher OD than seropositive MSM (OD=0.51 vs. 0.41, p=0.02)