Table 3.
EASR Grade by Patient Characteristics
| Variable | Week 3 grade | Week 6 grade | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 0 | 1 | 2 | 3 | ||||||||||
| N | % | N | % | N | % | P1 | N | % | N | % | N | % | N | % | P1 | |
| Total Patient | 25 | 15.8 | 125 | 79.1 | 8 | 5.0 | 2 | 1.3 | 77 | 48.4 | 73 | 45.9 | 7 | 4.4 | ||
| Age (years) | ||||||||||||||||
| <50 | 6 | 13.3 | 34 | 75.6 | 5 | 11.4 | 0.35 | - | - | 19 | 42.2 | 25 | 55.6 | 1 | 2.2 | 0.13 |
| 50–59 | 10 | 18.5 | 43 | 79.6 | 1 | 1.9 | 1 | 1.9 | 29 | 53.7 | 19 | 35.2 | 5 | 9.3 | ||
| ≥60 | 9 | 15.3 | 48 | 81.4 | 2 | 3.2 | 1 | 1.7 | 29 | 48.3 | 29 | 48.3 | 1 | 1.7 | ||
| Ethnicity | ||||||||||||||||
| Non-Hispanic | 9 | 15.5 | 43 | 74.1 | 6 | 10.3 | 0.07 | 1 | 1.7 | 29 | 50.0 | 24 | 41.4 | 4 | 6.9 | 0.24 |
| Hispanic | 16 | 16.0 | 82 | 82.0 | 2 | 2.0 | 1 | 1.0 | 48 | 47.5 | 49 | 48.5 | 3 | 3.0 | ||
| Race/Ethnicity | ||||||||||||||||
| AA | 5 | 17.9 | 20 | 71.4 | 3 | 10.3 | 0.10 | 1 | 3.4 | 12 | 41.4 | 12 | 41.4 | 4 | 13.8 | 0.22 |
| HW | 16 | 16.7 | 78 | 81.3 | 2 | 2.1 | 1 | 1.0 | 46 | 47.9 | 47 | 49.0 | 2 | 2.1 | ||
| NHW | 2 | 6.9 | 24 | 82.8 | 3 | 10.3 | 0 | 0 | 15 | 51.7 | 13 | 44.8 | 1 | 3.4 | ||
| Other | 2 | 40.0 | 3 | 60.0 | 0 | 0 | 0 | 0 | 4 | 80.0 | 1 | 20.0 | 0 | 0 | ||
| AA | 5 | 17.9 | 20 | 71.4 | 3 | 10.7 | 0.22 | 1 | 3.4 | 12 | 41.4 | 12 | 41.4 | 4 | 13.8 | 0.02 |
| Non-AA | 21 | 16.2 | 104 | 80.0 | 5 | 3.8 | 1 | 0.8 | 65 | 50.0 | 61 | 46.9 | 3 | 2.3 | ||
| BMI(kg/m2) | ||||||||||||||||
| <25 | 9 | 19.1 | 37 | 78.7 | 1 | 2.1 | 0.83 | - | - | 30 | 63.8 | 16 | 34.0 | 1 | 2.1 | 0.06 |
| 25 – 29.99 | 7 | 14.0 | 40 | 80.0 | 3 | 5.9 | 1 | 2.0 | 25 | 49.0 | 24 | 47.1 | 1 | 2.0 | ||
| ≥30 | 9 | 14.8 | 48 | 78.7 | 4 | 6.6 | 1 | 1.6 | 22 | 36.1 | 33 | 54.1 | 5 | 8.2 | ||
| <30 | 16 | 16.5 | 77 | 79.4 | 4 | 4.1 | 0.78 | 1 | 1.0 | 55 | 56.1 | 40 | 40.8 | 2 | 2.0 | 0.02 |
| ≥30 | 9 | 14.8 | 48 | 78.7 | 4 | 6.6 | 1 | 1.6 | 22 | 36.1 | 33 | 54.1 | 5 | 8.2 | ||
| Clinical stage | ||||||||||||||||
| 0 | 7 | 21.2 | 25 | 75.8 | 1 | 3.0 | 0.60 | 2 | 6.1 | 20 | 60.6 | 10 | 30.3 | 1 | 3.0 | 0.29 |
| IA–IB | 9 | 11.5 | 65 | 83.3 | 4 | 5.1 | - | - | 36 | 45.6 | 39 | 49.4 | 4 | 5.1 | ||
| IIA–IIIC | 9 | 19.1 | 35 | 74.5 | 3 | 6.4 | - | - | 21 | 44.7 | 24 | 51.1 | 2 | 4.3 | ||
| Smoking History | ||||||||||||||||
| Never | 19 | 17.8 | 83 | 77.6 | 5 | 4.7 | 0.61 | 1 | 0.9 | 53 | 49.1 | 49 | 45.4 | 5 | 4.7 | 1.00 |
| Ever | 6 | 11.8 | 42 | 82.4 | 3 | 5.9 | 1 | 2.0 | 24 | 47.1 | 24 | 47.1 | 2 | 3.9 | ||
| Smoking Status | ||||||||||||||||
| Never | 19 | 17.8 | 83 | 77.6 | 5 | 4.7 | 0.78 | 1 | 0.9 | 53 | 49.1 | 49 | 45.4 | 5 | 4.7 | 0.01 |
| Former | 5 | 11.1 | 37 | 82.2 | 3 | 6.7 | 1 | 2.2 | 20 | 44.4 | 24 | 53.3 | 0 | 0 | ||
| Current | 1 | 16.7 | 5 | 83.3 | 0 | 0 | 0 | 0 | 4 | 66.7 | 0 | 0- | 2 | 33.3 | ||
| # Comorbidities | ||||||||||||||||
| 0 | 7 | 10.9 | 55 | 85.9 | 2 | 3.1 | 0.25 | 0 | 0 | 37 | 56.9 | 26 | 40.0 | 2 | 3.1 | 0.15 |
| 1 | 10 | 17.9 | 40 | 71.4 | 6 | 10.7 | 0 | 0 | 25 | 44.6 | 30 | 53.6 | 1 | 1.8 | ||
| 2 | 6 | 21.4 | 22 | 78.6 | 0 | 0 | 2 | 7.1 | 12 | 42.9 | 12 | 42.9 | 2 | 7.1 | ||
| ≥3 | 2 | 20.0 | 8 | 80.0 | 0 | 0 | 0 | 0 | 3 | 30.0 | 5 | 50.0 | 2 | 20.0 | ||
| RT Dose (Gy) | ||||||||||||||||
| <60 | 2 | 6.3 | 28 | 87.5 | 2 | 6.3 | 0.30 | 0 | 0 | 17 | 51.5 | 14 | 42.4 | 2 | 6.1 | 0.90 |
| 60 | 18 | 16.7 | 84 | 77.8 | 6 | 5.6 | 1 | 0.9 | 52 | 48.1 | 51 | 47.2 | 4 | 3.7 | ||
| >60 | 5 | 27.8 | 13 | 72.2 | 0 | 0 | 1 | 5.6 | 8 | 44.4 | 8 | 44.4 | 1 | 5.6 | ||
| Breast Volume (cc) | ||||||||||||||||
| <864 | 13 | 16.9 | 62 | 80.5 | 2 | 2.6 | 0.65 | 2 | 2.6 | 42 | 54.5 | 33 | 42.9 | 0 | 0 | 0.007 |
| ≥864 | 12 | 15.6 | 60 | 77.9 | 5 | 6.5 | 0 | 0 | 33 | 42.3 | 38 | 48.7 | 7 | 9.0 | ||
1
P-value of chi-square test or Fisher’s exact test excluding missing; for week 6, grade 0/1 vs. 2 vs. 3.