Table 5.
Variable | Level | Week 3 Grade (n=158) | Week 6 Grade (n=159) | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | 0/1 | 2 | Multivariable | Total | 0/1 | 2/3 | Multivariable | ||||||||||
N | % | N | % | N | % | OR (95%CI)1 | P | N | % | N | % | N | % | OR(95%CI)1 | P | ||
Pre-RT CRP (mg/L) | < 2 | 58 | 36.7 | 57 | 38.0 | 1 | 12.5 | Reference | 58 | 36.5 | 34 | 43.0 | 24 | 30.0 | Reference | ||
≥ 2 | 100 | 63.3 | 93 | 62.0 | 7 | 87.5 | 4.90 (0.50, 48.32) | 0.17 | 101 | 63.5 | 45 | 57.0 | 56 | 70.0 | 1.56 (0.76, 3.21) | 0.22 | |
BMI | <30 | 97 | 61.4 | 93 | 62.0 | 4 | 50.0 | Reference | 98 | 61.6 | 56 | 70.9 | 42 | 52.5 | Reference | ||
≥30 | 61 | 38.6 | 57 | 38.0 | 4 | 50.0 | 1.18(0.23, 6.21) | 0.85 | 61 | 38.4 | 23 | 29.1 | 38 | 47.5 | 1.94 (0.94, 4.02) | 0.08 | |
Pre-RT CRP≥2 and BMI≥30 vs. CRP<2 and BMI<30 | 5.81 (0.49, 69.23)2 | 0.16 | 3.03 (1.28, 7.17)2 | 0.01 | |||||||||||||
Post-RT CRP (mg/L) | < 2 | 56 | 35.4 | 53 | 35.3 | 3 | 37.5 | Reference | 56 | 35.2 | 33 | 41.8 | 23 | 28.8 | Reference | ||
≥ 2 | 102 | 64.6 | 97 | 64.7 | 5 | 62.5 | 0.82 (0.13, 5.15) | 0.84 | 103 | 64.8 | 46 | 58.2 | 57 | 71.3 | 1.38 (0.65, 2.94) | 0.40 | |
BMI | <30 | 97 | 61.4 | 93 | 62.0 | 4 | 50.0 | Reference | 98 | 61.6 | 56 | 70.9 | 42 | 52.5 | Reference | ||
≥30 | 61 | 38.6 | 57 | 38.0 | 4 | 50.0 | 2.02 (0.30, 13.63) | 0.47 | 61 | 38.4 | 23 | 29.1 | 38 | 47.5 | 1.96 (0.92, 4.17) | 0.08 | |
Post-RT CRP≥2 and BMI≥30 vs. CRP<2 and BMI<30 | 1.66 (0.27, 10.32)2 | 0.59 | 2.70 (1.18, 6.19)2 | 0.02 | |||||||||||||
Post- minus pre-RT CRP | ≤ 1 | 125 | 79.1 | 118 | 78.7 | 7 | 87.5 | Reference | 126 | 79.2 | 69 | 87.3 | 57 | 71.3 | Reference | ||
> 1 | 33 | 20.9 | 32 | 21.3 | 1 | 12.5 | 0.47 (0.05, 4.38) | 0.51 | 33 | 20.8 | 10 | 12.7 | 23 | 28.8 | 2.51 (1.06, 5.95) | 0.04 | |
BMI | <30 | 97 | 61.4 | 94 | 62.0 | 4 | 50.0 | Reference | 98 | 61.6 | 56 | 70.9 | 42 | 52.5 | Reference | ||
≥30 | 61 | 38.6 | 57 | 38.0 | 4 | 50.0 | 2.09 (0.40,11.14) | 0.39 | 61 | 38.4 | 23 | 29.1 | 38 | 47.5 | 2.08 (1.03, 4.21) | 0.04 | |
CRP change>1 and BMI≥30 vs. change≤1 and BMI<30 | 0.97(0.08, 11.97)2 | 0.98 | 5.21 (1.77, 15.38)2 | 0.003 |
OR estimates of CRP variables (high vs. low category, mg/L), BMI (≥30 vs. <30 kg/m2), or combination, obtained from logistic regression models including the specific CRP variable, BMI, age (years), ethnicity (Hispanic vs. non-Hispanic), race (AA vs. others), and tumor stage (II–IV or I, vs. 0).
Interactions between specific CRP variable with BMI were not significant, OR estimates for combination high CRP and obesity vs. low CRP and non-obesity were calculated by multiplying the individual ORs.