Table 5.
Association between EASRs and CRP and/or Obesity
| Variable | Level | Week 3 Grade (n=158) | Week 6 Grade (n=159) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | 0/1 | 2 | Multivariable | Total | 0/1 | 2/3 | Multivariable | ||||||||||
| N | % | N | % | N | % | OR (95%CI)1 | P | N | % | N | % | N | % | OR(95%CI)1 | P | ||
| Pre-RT CRP (mg/L) | < 2 | 58 | 36.7 | 57 | 38.0 | 1 | 12.5 | Reference | 58 | 36.5 | 34 | 43.0 | 24 | 30.0 | Reference | ||
| ≥ 2 | 100 | 63.3 | 93 | 62.0 | 7 | 87.5 | 4.90 (0.50, 48.32) | 0.17 | 101 | 63.5 | 45 | 57.0 | 56 | 70.0 | 1.56 (0.76, 3.21) | 0.22 | |
| BMI | <30 | 97 | 61.4 | 93 | 62.0 | 4 | 50.0 | Reference | 98 | 61.6 | 56 | 70.9 | 42 | 52.5 | Reference | ||
| ≥30 | 61 | 38.6 | 57 | 38.0 | 4 | 50.0 | 1.18(0.23, 6.21) | 0.85 | 61 | 38.4 | 23 | 29.1 | 38 | 47.5 | 1.94 (0.94, 4.02) | 0.08 | |
| Pre-RT CRP≥2 and BMI≥30 vs. CRP<2 and BMI<30 | 5.81 (0.49, 69.23)2 | 0.16 | 3.03 (1.28, 7.17)2 | 0.01 | |||||||||||||
| Post-RT CRP (mg/L) | < 2 | 56 | 35.4 | 53 | 35.3 | 3 | 37.5 | Reference | 56 | 35.2 | 33 | 41.8 | 23 | 28.8 | Reference | ||
| ≥ 2 | 102 | 64.6 | 97 | 64.7 | 5 | 62.5 | 0.82 (0.13, 5.15) | 0.84 | 103 | 64.8 | 46 | 58.2 | 57 | 71.3 | 1.38 (0.65, 2.94) | 0.40 | |
| BMI | <30 | 97 | 61.4 | 93 | 62.0 | 4 | 50.0 | Reference | 98 | 61.6 | 56 | 70.9 | 42 | 52.5 | Reference | ||
| ≥30 | 61 | 38.6 | 57 | 38.0 | 4 | 50.0 | 2.02 (0.30, 13.63) | 0.47 | 61 | 38.4 | 23 | 29.1 | 38 | 47.5 | 1.96 (0.92, 4.17) | 0.08 | |
| Post-RT CRP≥2 and BMI≥30 vs. CRP<2 and BMI<30 | 1.66 (0.27, 10.32)2 | 0.59 | 2.70 (1.18, 6.19)2 | 0.02 | |||||||||||||
| Post- minus pre-RT CRP | ≤ 1 | 125 | 79.1 | 118 | 78.7 | 7 | 87.5 | Reference | 126 | 79.2 | 69 | 87.3 | 57 | 71.3 | Reference | ||
| > 1 | 33 | 20.9 | 32 | 21.3 | 1 | 12.5 | 0.47 (0.05, 4.38) | 0.51 | 33 | 20.8 | 10 | 12.7 | 23 | 28.8 | 2.51 (1.06, 5.95) | 0.04 | |
| BMI | <30 | 97 | 61.4 | 94 | 62.0 | 4 | 50.0 | Reference | 98 | 61.6 | 56 | 70.9 | 42 | 52.5 | Reference | ||
| ≥30 | 61 | 38.6 | 57 | 38.0 | 4 | 50.0 | 2.09 (0.40,11.14) | 0.39 | 61 | 38.4 | 23 | 29.1 | 38 | 47.5 | 2.08 (1.03, 4.21) | 0.04 | |
| CRP change>1 and BMI≥30 vs. change≤1 and BMI<30 | 0.97(0.08, 11.97)2 | 0.98 | 5.21 (1.77, 15.38)2 | 0.003 | |||||||||||||
1
OR estimates of CRP variables (high vs. low category, mg/L), BMI (≥30 vs. <30 kg/m2), or combination, obtained from logistic regression models including the specific CRP variable, BMI, age (years), ethnicity (Hispanic vs. non-Hispanic), race (AA vs. others), and tumor stage (II–IV or I, vs. 0).
2
Interactions between specific CRP variable with BMI were not significant, OR estimates for combination high CRP and obesity vs. low CRP and non-obesity were calculated by multiplying the individual ORs.