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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2014 Oct 28;24(1):128–137. doi: 10.1158/1055-9965.EPI-14-0560

Table 1.

Height and Overall Adiposity Associations with ER+PR+ Breast Cancer in Postmenopausal Women not currently Using Hormone Therapy, by Ethnicity

All Hispanics Non-Hispanic Whites
ER+PR+
Cases
n=586		 Controls
n=1,775		 ER+PR+
Cases
n=294		 Controls
n=961		 ER+PR+
Cases
n=292		 Controls
n=814
n n OR (95%CI) 1 n n OR (95%CI) 1 n n OR (95%CI) 2
Current height (m) 3,4
    Q1: <153.2 139 442 1.0 111 354 1.0 28 88 1.0
    Q2: 153.2–157.7 138 443 0.95 0.72–1.26 77 283 0.85 0.61–1.20 61 160 1.22 0.72–2.09
    Q3: 157.8–162.9 147 443 0.97 0.73–1.30 72 213 1.01 0.71–1.44 75 230 1.05 0.63–1.76
    Q4: >162.9 161 440 1.06 0.78–1.45 33 108 0.92 0.57–1.48 128 332 1.26 0.76–2.09
P trend = 0.65 P trend = 0.88 P trend = 0.47
Current height (m) 4,5
    Quartile 1 65 240 1.0 69 213 1.0
    Quartile 2 81 251 1.16 0.79–1.71 78 192 1.24 0.84–1.83
    Quartile 3 62 228 0.97 0.65–1.46 66 203 1.01 0.68–1.51
    Quartile 4 85 239 1.26 0.85–1.88 79 202 1.23 0.82–1.85
P trend = 0.42 P trend = 0.52
    Per 5 cm 1.07 0.98–1.16 1.09 0.97–1.22 1.04 0.93–1.17
Young-adult BMI (kg/m2) 3,6,7
    Q1: <20.4 159 426 1.0 67 161 1.0 92 265 1.0
    Q2: 20.4–22.1 133 424 0.84 0.64–1.11 55 208 0.61 0.40–0.94 78 216 1.03 0.71–1.49
    Q3: 22.2–24.4 145 427 0.87 0.66–1.16 74 256 0.69 0.46–1.05 71 171 1.07 0.72–1.59
    Q4: >24.4 121 426 0.69 0.50–0.95 74 281 0.61 0.40–0.95 47 145 0.68 0.42–1.11
P trend = 0.04 P trend = 0.07 P trend = 0.27
Young-adult BMI (kg/m2) 6,7,8
    Quartile 1 85 227 1.0 71 201 1.0
    Quartile 2 59 226 0.69 0.47–1.02 70 197 0.99 0.66–1.47
    Quartile 3 65 226 0.79 0.53–1.17 79 199 1.01 0.67–1.52
    Quartile 4 61 227 0.71 0.46–1.09 68 200 0.73 0.46–1.14
P trend = 0.18 P trend = 0.23
    Per 5 kg/m2 0.81 0.68–0.96 0.83 0.66–1.04 0.77 0.59–1.00
Current BMI (kg/m2) 9,10
    <25.0 158 517 1.0 57 180 1.0 101 337 1.0
    25.0–29.9 202 615 1.02 0.77–1.35 99 364 0.81 0.52–1.25 103 251 1.16 0.79–1.70
    ≥30.0 225 635 0.96 0.67–1.37 137 413 0.91 0.55–1.51 88 222 0.89 0.52–1.52
P trend = 0.80 P trend = 0.84 P trend = 0.77
    Per 5 kg/m2 0.87 0.74–1.02 0.81 0.65–1.01 0.94 0.74–1.19
Weight gain (kg) 3,7,11
    Q1: <8.6 128 388 1.0 52 188 1.0 76 200 1.0
    Q2: 8.6–14.5 100 396 0.83 0.61–1.13 53 218 0.96 0.62–1.50 47 178 0.71 0.46–1.10
    Q3: 14.6–22.7 124 348 1.17 0.86–1.61 64 202 1.32 0.84–2.09 60 146 1.05 0.67–1.65
    Q4: >22.7 165 418 1.40 0.96–2.06 82 234 1.68 0.98–2.89 83 184 1.15 0.66–2.00
P trend = 0.04 P trend = 0.04 P trend = 0.49
Weight gain (kg) 7,11,12
    Quartile 1 62 232 1.0 62 177 1.0
    Quartile 2 51 192 1.06 0.69–1.63 49 162 0.91 0.58–1.43
    Quartile 3 65 212 1.31 0.85–2.02 72 185 1.10 0.70–1.72
    Quartile 4 73 206 1.75 1.02–3.02 83 184 1.29 0.73–2.29
P trend = 0.04 P trend = 0.36
    Per 5 kg 1.09 1.01–1.18 1.11 1.00–1.22 1.08 0.96–1.21
Young-adult BMI (kg/m2) 6,13 and weight gain (kg) 7,11
    <22.2 / per 5kg 292 850 1.26 1.05–1.50 122 369 1.42 1.09–1.86 170 481 1.15 0.90–1.47
    ≥22.2 / per 5kg 266 853 1.05 0.93–1.19 148 537 1.03 0.87–1.21 118 316 1.09 0.89–1.33
1

Odds ratios and 95% confidence intervals, adjusted for age (years, continuous), study (SFBCS, 4-CBCS), ethnicity/ English language acculturation (low, moderate, high, non-Hispanic white), education (less than high school, high school graduate, post high school education), family history of breast cancer in first degree relatives (no, yes), age at menarche (<12, 12, 13, ≥14), number of full-term pregnancies (nulliparous, 1–2, 3–4, ≥5), age at first full-term pregnancy (<20, 20–24, 25–29, ≥30, nulliparous), lifetime number of months of breastfeeding (nulliparous, 0, 1–6, 7–12, 13–24, >24), and average alcohol consumption in reference year (g/day; 0, 0.1–4.9, 5–9.9, 10–19.9, ≥20).

2

Adjusted for all variables above except English language acculturation.

3

Based on quartiles among postmenopausal controls not currently using hormone therapy.

4

Based on measured height at interview (or self-reported adult height when measured height was not available).

5

Based on ethnicity-specific quartiles among postmenopausal controls not currently using hormone therapy in each ethnic group. Quartile cutpoints by ethnicity are <151.2, 151.2–154.9, 155.0–159.4, and >159.4 for Hispanics, and <156.9, 156.9–161.5, 161.6–165.5, and >165.5 for NHWs.

6

Based on self-reported averaged weight at age 15 and age 30 for 4-CBCS cases and controls, self-reported weight in the 20's for SFBCS cases and controls (between ages 25–30 for cases diagnosed from April 1995 to April 1998 and matched controls and between ages 20–29 for cases diagnosed from May 1998 to April 2002 and matched controls), and measured height at interview (or self-reported adult height when measured height was not available).

7

Adjusted additionally for current BMI (continuous).

8

Based on ethnicity-specific quartiles among postmenopausal controls not currently using hormone therapy in each ethnic group. Quartile cutpoints by ethnicity are <21.0, 21.0–22.7, 22.8–25.1, and >25.1 for Hispanics, and <19.9, 19.9–21.5, 21.6–23.3, and >23.3 for NHWs.

9

Based on self-reported weight in reference year (or measured weight at interview when self-reported weight in reference year was not available) and measured height at interview (or self-reported adult height when measured height was not available).

10

Adjusted additionally for weight gain (continuous).

11

Based on self-reported weight in reference year (or measured weight at interview when self-reported weight was not available) minus self-reported young-adult weight.

12

Based on ethnicity-specific quartiles among postmenopausal controls not currently using hormone therapy in each ethnic group. Quartile cutpoints by ethnicity are <9.1, 9.1–15.4, 15.5–23.6, and >23.6 for Hispanics, and <7.1, 7.1–13.6, 13.7–22.7, and >22.7 for NHWs.

13

Based on median among postmenopausal controls not currently using hormone therapy.