FIGURE 2. Regions of Age-Specific Differences in Activation Between Tourette Syndrome and Healthy Comparison Subjects.

^a Activation increased with age in persons with Tourette syndrome, declined in the healthy comparison subjects. Correlations of activation with age in the Tourette group (r=0.30, p=0.03) and comparison group (r=−0.22, p=0.07) were compared through Fisher z transformation (z=2.81), with the positive z score indicating a significantly larger correlation coefficient in the Tourette group relative to the comparison subjects (p=0.005).

^b Activation increased with age in persons with Tourette syndrome, declined in the healthy comparison subjects. Correlations of activation with age in the Tourette group (r=0.37, p=0.008) and comparison group (r=−0.17, p=0.16) were compared through Fisher z transformation (z=2.92), with the positive z score indicating a significantly larger correlation coefficient in the Tourette group relative to the comparison subjects (p=0.003).

^c Activation increased with age in persons with Tourette syndrome more than in the healthy comparison subjects. Correlations of activation with age in the Tourette group (r=0.34, p=0.01) and comparison group (r=0.20, p=0.09) were compared through Fisher z transformation (z=2.96), with the positive z score indicating a significantly larger correlation coefficient in the Tourette group relative to the comparison subjects (p=0.003).

^d Activation increased with age in persons with Tourette syndrome, declined in the healthy comparison subjects. Correlations of activation with age in the Tourette group (r=0.51, p < 0.0001) and comparison group (r=−0.24, p=0.04) were compared through Fisher z transformation (z=4.25), with the positive z score indicating a significantly larger correlation coefficient in the Tourette group relative to the comparison subjects (p < 0.0001).