Table 1.

Human XPD-like helicases

Helicase	activities	pathways	diseases
XPD/Rad3 (ERCC2)	Helicase [18, 19], damage verification [20]	Nucleotide excision repair (NER), transcription [27]	Xeroderma Pigmentosum (XP), Cockayne Syndrome (CS), Trichothiodystrophy (TTD), Cerebro-oculo-facial-skeletal developmental abnormalities (COFS) [33, 34]
FANCJ (BACH1)	Helicase[21], tumor suppressor[21], anti-recombinase, translocase[22], resolution of G-quadruplexes [23]	Homologous recombination (HR)[21], interstrand cross-link (ICL) repair[28, 29]	Breast Cancer [21], Fanconi Anemia [28, 29]
RTEL	Helicase, anti-recombinase[24], translocase, dismantles G4 structures at telomeres[25]	HR [24], telomere homeostasis[25], replication[30], regulation of meiotic cross-over events [31]	Cancer[35, 36], Dyskeratosis congenita[37], Crohn’s Disease[38], hypertension[39]
CHLR1 (DDX11)	Helicase[26]	sister chromatid cohesion and DNA repair [32]	Warsaw Breakage Syndrome [40]