Table 1. Top 50 genes with largest difference in expression in the different exposition settings in HMEC-1.
| BLEOMYCIN - ACUTE | BLEOMYCIN - CHRONIC | CISPLATIN - ACUTE | CISPLATIN - CHRONIC | ||||
|---|---|---|---|---|---|---|---|
| Gene | ΣZ | Gene | P-value | Gene | ΣZ | Gene | P-value |
| ATF3 * ‡ | ↑ 9.574 | CYP1B1 | ↑ <0.0001 | CORT | ↑ 9.577 | MX1† | ↓ <0.0001 |
| KIAA1370 | ↑ 9.574 | KLF12 | ↑ <0.0001 | TREM2 | ↑ 9.222 | GPR87 | ↓ <0.0001 |
| RRAD | ↑ 9.552 | PRSS35 ‡ | ↑ <0.001 | ATF3 * § | ↑ 9.039 | IFI27 | ↓ <0.0001 |
| C12orf5 | ↑ 9.476 | GLS2 | ↓ <0.001 | AVPI1 | ↑ 8.757 | JMJD4 | ↑ <0.001 |
| GDF-15 ‡ | ↑ 9.454 | ENPP4 | ↑ <0.001 | AK1* | ↑ 8.658 | FAM155A | ↓ <0.001 |
| GPR87 | ↑ 9.454 | ZMAT1 | ↑ <0.001 | VASN | ↑ 8.653 | OAS3 | ↓ <0.001 |
| MDM2 | ↑ 9.356 | TMEM184C | ↑ <0.001 | SESN2 * | ↑ 8.633 | MX2 | ↓ <0.001 |
| SESN2 * | ↑ 9.258 | ADAM12† | ↑ <0.001 | LRDD | ↑ 8.633 | HLA-F | ↓ <0.001 |
| COL7A1 | ↑ 9.16 | RAB11FIP1 | ↑ <0.001 | AREG§ | ↑ 8.633 | AREG † § | ↓ <0.001 |
| ATG16L2 | ↑ 9.16 | PTGER2 | ↑ <0.001 | PLCD1 | ↑ 8.586 | LOC158376 | ↑ <0.001 |
| AK1* | ↑ 9.16 | SERPINB2 | ↑ <0.001 | ADM | ↑ 8.549 | ALKBH8 | ↑ <0.001 |
| FAS | ↑ 8.964 | SCFD2 | ↑ <0.01 | LRRTM2 | ↑ 8.524 | ABCC4 | ↑ <0.001 |
| LIF | ↑ 8.964 | KRTAP4-8 | ↑ <0.01 | DEDD2 | ↑ 8.457 | HIST2H2BE | ↓ <0.001 |
| VWCE | ↑ 8.866 | C10orf136 | ↑ <0.01 | RALGDS | ↑ 8.37 | RFT1 | ↑ <0.001 |
| TP53INP1 | ↑ 8.817 | HES1† | ↓ <0.01 | DNAJB2 | ↑ 8.364 | LRRC38 | ↑ <0.001 |
| VDR | ↑ 8.811 | COL1A2 | ↑ <0.01 | MSX1 | ↑ 8.328 | SNAI1† | ↓ <0.001 |
| C4orf18 | ↑ 8.768 | HIST1H2BJ | ↑ <0.01 | MST150 | ↑ 8.322 | C19orf42 | ↑ <0.01 |
| FERMT1 | ↑ 8.734 | RBPJL | ↑ <0.01 | NR4A3 | ↑ 8.157 | LOC151171 | ↓ <0.01 |
| FUCA1 | ↑ 8.691 | CRTAC1 | ↓ <0.01 | FDXR | ↑ 8.143 | SIAE | ↓ <0.01 |
| MCC | ↑ 8.691 | CCDC148† | ↓ <0.01 | ITPKA | ↑ 8.143 | IQGAP2 | ↓ <0.01 |
| NELF | ↑ 8.691 | ROR1 | ↑ <0.01 | KREMEN2§ | ↑ 8.143 | POLA1 | ↑ <0.01 |
| BTG2 | ↑ 8.691 | EDN1 | ↓ <0.01 | SLC31A2 | ↑ 8.126 | PDK4 | ↓ <0.01 |
| TGFBR1 | ↑ 8.691 | TGFB2 ‡ | ↑ <0.01 | CEACAM1 | ↑ 8.107 | ATF3 † § | ↓ <0.01 |
| TMEM131 | ↑ 8.572 | PRKCZ | ↑ <0.01 | IRF5 | ↑ 8.101 | TNFSF10 | ↓ <0.01 |
| CDH10 | ↑ 8.572 | MARVELD2 | ↑ <0.01 | FOXL2 | ↑ 8.101 | DHX37 | ↑ <0.01 |
| FZD2 | ↓ -7.775 | ATF3 † ‡ | ↓ <0.01 | VCAM1 * | ↓ -8.432 | TOMM40L | ↑ <0.01 |
| C3orf36 | ↓ -7.809 | CD82 | ↓ <0.01 | C7orf10 | ↓ -8.437 | IFIT3 | ↓ <0.01 |
| TRIB2 * | ↓ -7.817 | XTP3TPA | ↑ <0.01 | C3orf26 | ↓ -8.438 | IFI44L | ↓ <0.01 |
| SMA5 | ↓ -7.835 | SPTAN1 | ↓ <0.01 | MYRIP | ↓ -8.535 | TNC† | ↑ <0.01 |
| NDRG4 | ↓ -7.869 | KIAA1655 | ↑ <0.01 | ROR1 | ↓ -8.56 | KREMEN2 § | ↓ <0.01 |
| EBPL | ↓ -7.873 | DDB2 | ↓ <0.01 | QKI | ↓ -8.597 | HNMT | ↓ <0.01 |
| TGFB2 ‡ | ↓ -7.912 | SNAI1† | ↓ <0.01 | TRIB2 * | ↓ -8.628 | BRD9 | ↑ <0.01 |
| MYCN | ↓ -7.971 | STC2 | ↑ <0.01 | CDKAL1 | ↓ -8.647 | BEX2 | ↓ <0.01 |
| SEMA3A * | ↓ -7.971 | TNC† | ↑ <0.01 | TFPI | ↓ -8.658 | MGC33894 | ↓ <0.01 |
| GIMAP2 | ↓ -7.992 | LRRIQ1 | ↓ <0.01 | LTBP1 | ↓ -8.664 | DUSP1† | ↓ <0.01 |
| ZFP36 | ↓ -8.001 | ASMT | ↑ <0.01 | PLK1 | ↓ -8.686 | C7orf54 | ↓ <0.01 |
| UBE2G2 | ↓ -8.044 | GATA6 | ↑ <0.01 | NAV1 | ↓ -8.714 | ID4 | ↑ <0.01 |
| RNASE1 | ↓ -8.069 | GDF-15 † ‡ | ↓ <0.01 | PAPPA | ↓ -8.726 | CCDC148† | ↓ <0.01 |
| MXD3 | ↓ -8.21 | PCDHGA3 | ↓ <0.01 | PIF1* | ↓ -8.765 | MDM2 | ↓ <0.01 |
| HIST1H2AM | ↓ -8.218 | DDX19A | ↑ <0.01 | DHRSX | ↓ -8.891 | PRAP1 | ↓ <0.01 |
| C14orf94 | ↓ -8.222 | RARB | ↑ <0.01 | GMDS | ↓ -8.928 | FOS | ↓ <0.01 |
| PIF1* | ↓ -8.261 | CCND2 | ↓ <0.01 | LAMA4 | ↓ -9.02 | HES1† | ↓ <0.01 |
| OASL | ↓ -8.265 | BCS1L | ↑ <0.01 | DKFZP0335 | ↓ -9.02 | ASPA | ↓ <0.01 |
| PRSS35 ‡ | ↓ -8.44 | BIRC7 | ↑ <0.01 | CD9 | ↓ -9.051 | GDF-15 † | ↓ <0.01 |
| CLEC14A * | ↓ -8.482 | MX1† | ↓ <0.01 | FAT4 | ↓ -9.124 | COL9A3 | ↓ <0.01 |
| HOXD8 | ↓ -8.679 | RERG | ↑ <0.01 | DOCK1 | ↓ -9.222 | LGALS9 | ↓ <0.01 |
| HIST1H1D | ↓ -8.713 | ADAMTS12 | ↑ <0.01 | SMAD7 | ↓ -9.32 | NR4A1 | ↓ <0.01 |
| CLEC3B | ↓ -8.866 | DUSP1† | ↓ <0.01 | FHOD3 | ↓ -9.381 | ADAM12† | ↑ <0.01 |
| VCAM1 * | ↓ -9.16 | AREG† | ↓ <0.01 | CLEC14A * | ↓ -9.418 | RNASE7 | ↓ <0.01 |
| C9orf3 | ↓ -9.552 | OSBPL1A | ↑ <0.01 | SEMA3A * | ↓ -9.418 | HHATL | ↓ <0.01 |
* Overlapping genes in the “acute” exposure setting for both drugs,
† Overlapping genes in the “chronic” exposure setting for both drugs.
‡ Overlapping genes in the “acute” and “chronic” exposure setting for bleomycin.
§ Overlapping genes in the “acute” and “chronic” exposure setting for cisplatin.