Table 2. Effect size of combinations of interventions.

Intervention 1	Intervention 2	Effect size 1	Effect size 2	Product of effect sizes	Effect size of combination	Ratio of combination to product
ITN, moderate	MDA, low season	6.845	1.594	10.91	10.98	1.006
efficacy	MDA, at peak	6.845	1.459	9.99	10.08	1.009
	Vaccine, mod. triennial	6.845	1.433	9.81	9.81	1.001
	Vaccine, mod. annual	6.845	1.484	10.16	10.18	1.002
	Vaccine, high triennial	6.845	2.642	18.09	18.11	1.001
	Vaccine, high annual	6.845	2.985	20.44	20.62	1.009
ITN, high	MDA, low season	21.98	1.594	35.04	35.33	1.008
efficacy	MDA, at peak	21.98	1.459	32.07	32.53	1.014
	Vaccine, mod. triennial	21.98	1.433	31.50	31.52	1.001
	Vaccine, mod. annual	21.98	1.484	32.62	32.71	1.003
	Vaccine, high triennial	21.98	2.642	58.08	58.19	1.002
	Vaccine, high annual	21.98	2.985	65.62	66.44	1.012
MDA, low	Vaccine, mod. triennial	1.594	1.433	2.284	2.276	0.996
season	Vaccine, mod. annual	1.594	1.484	2.365	2.339	0.989
	Vaccine, high triennial	1.594	2.642	4.211	4.156	0.987
	Vaccine, high annual	1.594	2.985	4.758	4.579	0.962

Low season MDA means three months before the peak of the season. “Vaccine” refers to a pre-erythrocytic vaccine six weeks before the seasonal peak, “mod” and “high” refer to a moderate or high efficacy vaccine, and annual and triennial vaccines have one and three year half-lives respectively. There is a three month high season, and interventions are at 80% coverage except the high efficacy vaccine which is 90%.