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. 2015 Jan 15;10(1):e0113170. doi: 10.1371/journal.pone.0113170

Figure 6. Expression ranking of non-olfactory GPCRs (nGPCR).

Figure 6

A. Heatmap showing the ranking of the 30 most highly expressed nGPCRs in the FACS-sorted ORNs. Only six nGPCRs were among the 1,000 most highly expressed genes (Adipor1, Gpr178, Gabbr1, Gprc5c, Drd2, and Lphn3). Of the 30 most highly expressed genes, the expression of 17 in the OE was no previously known. B. Heat map showing the ranking of nGPCRs that are specifically enriched in ORNs according the criteria that the nGPCRs’ FPKMs were greater than 1 and 5 times greater in the ORNs than in non-olfactory tissue (brain, liver, muscle and testes). A total of 18 specifically enriched nGPCRs were found in ORNs. Excluding the specifically enriched candidates that were already presented in the list of the 30 most highly expressed genes, an additional 10 genes were found to be specifically enriched and are new in terms of olfaction. Regarding the genes that were among the 30 most highly expressed and were specifically enriched in ORNs, 60% had neither been shown to be expressed in the OE or been ascribed any function in the OE in any previous study with the exception of for several candidates in a tabular form in a recent transcriptome-wide study of the total OE [52].