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. 2015 Jan 15;11(1):e1004862. doi: 10.1371/journal.pgen.1004862

Figure 1. Ca2+ kinetics of single twitches in FDB fibres from WT and Actn3 KO mice.

Figure 1

A Superimposed representative twitch transients from an Actn3 KO and a WT fibre, showing faster [Ca2+]i decay in the KO fibre. Across our sample as a whole, there was no difference between WT and Actn3 KO fibres in the time taken to rise from 20% to 80% of peak (B). However, during decay, the rate constant of decay was significantly higher in Actn3 KO fibres than in WT fibres, both during the fast phase (C) and slow phase (D). (In B, C and D, n = 36 for WT and n = 31 for KO. In C and D, equivalent time constants, in ms, are: 2.2 ± 0.1 for WT and 1.6 ± 0.1 for KO in fast phase; 25.1 ± 0.9 for WT and 16.0 ± 0.2 for KO in slow phase.)