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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: Cancer Res. 2014 Jun 24;74(16):4482–4492. doi: 10.1158/0008-5472.CAN-13-1597

Figure 2.

Figure 2

PDGF induces ID4 via NOS-NO signaling. A, nitrite (NO2−) levels in X02, X03, and GSC1T GICs 12 hours after PDGF (50 ng/mL) treatment. B, ID4 expression after treatment with GSNO (100 and 200 μmol/L) in GICs (X02, X03, and GSC1T). C and D, NOS inhibitor (LNAME; 200 μmol/L) and sGC inhibitor (ODQ; 1 μmol/L) markedly suppressed PDGF-mediated induction of ID4 mRNA (C) and protein (D) expression in GICs; **, P < 0.01 (n = 3); data, mean ± SD.