Fig. 3.

Effects of MDP (3 mg/kg), FK565 (0.003 mg/kg) and LPS (doses as indicated) to reduce body temperature (A) and weight (B) in male mice. The graphs show the change in temperature 4 h post-treatment and body weight 21 h post-treatment. Body temperature and weight were measured before treatment and 4 and 26 h post-injection, respectively. The weight loss induced by the treatment is expressed as a percentage of the body weight measured pre-treatment. The values are means + SEM, n = 15 for VEH (merged from 2 separate experiments), n = 7–8 for other groups. Post-hoc analysis of significant NOD × LPS interactions in 2-way ANOVA: ^##p < 0.01, MDP + LPS versus MDP or FK565 + LPS versus FK565. ^§§p < 0.01, MDP + LPS and FK565 + LPS versus LPS (0.83 mg/kg). Main factor effects without NOD × LPS interactions: ^ap < 0.01, LPS versus VEH. ^bp < 0.01, LPS 0.83 mg/kg versus LPS 0.1 mg/kg.