Fig. 7.

Effects of MDP (3 mg/kg), FK565 (0.003 mg/kg) and LPS (0.1 mg/kg) on circulating corticosterone (CORT) levels 3 h (A) and 26 h (B) after treatment, as well as on the kynurenine/tryptophan (KYN/TRP) ratio (C) and circulating levels of kynurenine (D) and tryptophan (E) measured 26 h after treatment of male mice. Plasma CORT was measured 3 h after treatment (A) and 26 h after treatment, 30 min following exposure to tail suspension stress (B). Likewise, plasma kynurenine and tryptophan (C–E) were determined 26 h after treatment, 30 min following exposure to tail suspension stress. The values are means + SEM, n = 7–8. (A): Main factor effects without NOD × LPS interactions: ^ap < 0.001, LPS versus VEH. ^bp < 0.001, FK565 versus VEH or MDP. (B–E): One-way ANOVA: ⁺p < 0.1, ^∗p < 0.05, ^∗∗p < 0.01, versus VEH or as indicated by the brackets.