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. 2014 Sep 15;104(2):270–279. doi: 10.1093/cvr/cvu209

Figure 3.

Figure 3

Effect of isoprenaline on cardiac haemodynamics and size in WT vs. AKAP5−/− mice. (A) Two-month-old WT and AKAP5−/− were echoed before the placement of the Alzet mini-osmotic pump. Buffer (1% ascorbic acid in PBS) or isoprenaline (100 mg/mL of buffer) was infused by a model 2002 mini-osmotic pump at a rate of 0.5 µL/h for 10 days. Then, the pumps were removed and the mice were echoed the next day. The data were plotted as means ± SE and then compared among different groups. (B) After the second echocardiography, mice were weighed and the heart was excised, weighed, and followed by extraction of RNA. (C) mRNA expression levels of hypertrophy markers were determined by quantitative RT-PCR. *P < 0.05 and **P < 0.01 represent the P-value of either base in WT vs. base in KO mice or isoprenaline in WT vs. isoprenaline in KO.