Table 1.
Effect of CsA on echocardiographic parameters in WT vs. AKAP5 KO littermates
| Solvent AKAP5+/+ |
Cyclosporine A AKAP5+/+ |
Solvent AKAP5−/− |
Cyclosporine A AKAP5−/− |
|||||
|---|---|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | Before | After | |
| (n = 8) | (n = 8) | (n = 8) | (n = 8) | |||||
| EF (%) | 63.1 ± 4.6 | 63.6 ± 3.6 | 62.5 ± 2.9 | 60.6 ± 3.1 | 46.9 ± 2.5 | 46.6 ± 3.4 | 46.7 ± 2.7 | 50.5 ± 3.6 |
| FS (%) | 43.8 ± 2.2 | 44.0 ± 2.4 | 43.4 ± 2.3 | 42.8 ± 2.4 | 33.4 ± 1.5 | 33.0 ± 2.7 | 33.7 ± 3.3 | 35.5 ± 3.0 |
| LV Vold (µL) | 64.1 ± 4.6 | 65.0 ± 5.3 | 65.9 ± 4.3 | 59.7 ± 5.7 | 79.2 ± 6.3 | 79.3 ± 6.9 | 78.4 ± 6.1 | 76.4 ± 6.3 |
| LV Vols (µL) | 23.7 ± 3.4 | 23.8 ± 3.7 | 24.9 ± 2.8 | 22.7 ± 3.2 | 42.9 ± 4.6 | 42.5 ± 3.5 | 41.6 ± 5.5 | 38.2 ± 4.4 |
| SV (µL) | 40.4 ± 4.1 | 41.3 ± 4.3 | 41.0 ± 4.0 | 36.9 ± 4.4 | 37.2 ± 4.8 | 36.8 ± 4.3 | 36.7 ± 3.8 | 38.2 ± 4.2 |
| CO/BW | 0.74 | 0.75 | 1.02 | 0.93 | 0.77 | 0.71 | 0.69 | 0.74 |
Echocardiography was before and after the administration of 10 mg CsA /kg/day or solvent for 14 days to 4-month-old mice.
EF, ejection fraction; FS, Fractional sgortening; LV Vold, diastolic left ventricular volume; LV Vols, systolic left ventricular volume; SV, stroke volume; CO/BW, ratio of cardiac output/min/body weight in grams.