Table 3.
Association Results for Longevity: Discovery and Look-Up
| SNP | Chr | Gene | Distance (kb) | EA | EAF | Discovery | EU_longevity | Centenarian (NECS) | Survival (LLFS) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p Value | OR | 95% CI | Direction | effect | p Value | SNP | r 2* | OR | p Value | SNP | r 2* | 1/HR | p Value | ||||||
| rs1416280 | 6 | GRIK2 | 369 | C | 0.75 | 5.09×10−8 | 1.24 | 1.15–1.34 | +−+++++++−+ | + | .276 | rs9377361 | 1.00 | 0.98 | .833 | rs9377361 | 1.00 | 1.00 | .981 |
| rs9841144 | 3 | CADM2 | −236 | A | 0.79 | 9.66×10−7 | 0.81 | 0.74–0.88 | −−−−−−−−−+− | + | .825 | rs9822731 | 0.96 | 1.03 | .726 | rs9822731 | 0.96 | 0.85 | .053 |
| rs4611001 | 1 | RGS7 | −28 | A | 0.97 | 1.84×10−6 | 1.79 | 1.41–2.27 | +?−++++++?+ | − | .207 | rs7536260 | 0.68 | 0.65 | .013 | rs75361849 | 1.00 | 1.07 | .728 |
| rs11023737 | 11 | SOX6 | −28 | A | 0.32 | 3.64×10−6 | 0.83 | 0.77–0.90 | −−−−−−−−−−− | + | .684 | rs2196961 | 0.27 | 1.03 | .668 | rs11023744 | 0.96 | 1.06 | .397 |
| rs11753077 | 6 | MBOAT1 | −76 | T | 0.64 | 7.51×10−6 | 1.17 | 1.09–1.26 | +++++++−+−+ | + | .095 | rs7763815 | 0.87 | 1.04 | .572 | Same | 1.00 | 1.03 | .633 |
| rs10875746 | 12 | PFKM | Intron | A | 0.76 | 7.8 3×10−6 | 1.20 | 1.11–1.30 | +++++++++−+ | + | .240 | rs2228500 | 0.74 | 1.03 | .796 | rs2228500 | 0.74 | 0.93 | .349 |
| rs10007810 | 4 | LIMCH1 | Intron | A | 0.23 | 8.80×10−6 | 1.20 | 1.11–1.30 | +−+++++++++ | − | .979 | Same | 1.00 | 0.98 | .841 | Same | 1.00 | 0.95 | .521 |
| rs10457180 | 6 | FOXO3 | Intron | A | 0.70 | 8.56×10−5 | 0.87 | 0.81–0.93 | −−+−−−−−+−− | − | .023 | rs2153960 | 0.89 | 0.98 | .822 | rs2153960 | 0.89 | 0.84 | .021 |
Notes: EA = effect allele; EAF = effect allele frequency; “+” = effect allele over-represented in cases; “−” = effect allele underrepresented in cases; “?” = not tested in this cohort. The p values < .05 in replication are represented in bold. EU_longevity: European consortium investigating the genetics of longevity with similar phenotype to discovery (cases: 90+; controls: < 65 y old); Centenarians (NECS, New England Centenarian Study): centenarian cases compared to younger controls; Survival (LLFS, Long Life Family Study): all-cause mortality Cox-regression analysis, 1/HR shown for direct comparison of the direction of the effect. In NECS and LLFS, imputation is not available. Study order for direction column: RS1, RS2, SOF, CHS, MrOS, FHS, HRS, AGES, RADC, InCHIANTI, BLSA.
*Linkage disequilibrium with discovery SNP.