Fig. 6.

CVLS predicted disaccharide sequences from the UA_NRE (A) and GlcN_NRE libraries (B). Only three disaccharide sequences (blue sticks), each related to EF structure of pentasaccharide DEFGH, were found to satisfy the dual-filter strategy from the library of 78 UA_NRE sequences (A). None of the 78 possible disaccharides (blue sticks) belonging to the GlcN_NRE library bound antithrombin with “high specificity”. Helices A (hA), D (hD) and P (hP) of antithrombin are shown in ribbon form and residues Arg132, Arg129, Lys125 and Arg114 are shown in ball and stick display. The crystal structure of DEFGH in green ball and sticks display is shown to highlight correspondence with the CVLS predicted poses.