Table 1.
Baseline Demographic and Disease Characteristics, by Plasma Interferon γ–Inducible Protein 10 Level
| Characteristic | <600 pg/mL (n = 268) | >600 pg/mL (n = 159) | P Value |
|---|---|---|---|
| Demographic | |||
| Age, y | 51 ± 10.6 | 53 ± 9.0 | .0264 |
| Sex | |||
| Female | 113 (42.2) | 60 (37.7) | .3675 |
| Male | 155 (57.8) | 99 (62.3) | |
| Race | |||
| Black | 40 (14.9) | 17 (10.7) | .2137 |
| Not black | 228 (85.1) | 142 (89.3) | |
| Ethnicity | |||
| Hispanic | 32 (12.0) | 12 (7.6) | .1511 |
| Non-Hispanic | 235 (88.0) | 146 (92.4) | |
| Not provided | 1 | 1 | |
| BMIa | 27.5 ± 4.44 | 29.0 ± 5.20 | .0018 |
| Clinical | |||
| IL28B genotype | |||
| CC | 77 (28.7) | 29 (18.4) | .0167 |
| Non-CC | 191 (71.3) | 129 (81.7) | |
| Missing | 0 | 1 | |
| HCV RNA level, log10 IU/mL | 6.48 ± 0.704 | 6.57 ± 0.664 | .2155 |
| HCV genotype | |||
| 1a | 191 (71.3) | 109 (68.6) | .5529 |
| 1b | 77 (28.7) | 50 (31.5) | |
| ALT level, U/L | 70.5 (57.46) | 81.5 (63.09) | .0664 |
| vRVR | |||
| GS-US-248-0120 | |||
| Yes | 64 (78.1) | 29 (69.1) | .2733 |
| No | 18 (22.0) | 13 (31.0) | |
| GS-US-248-0131 | |||
| Yes | 47 (54.0) | 39 (52.0) | .7970 |
| No | 40 (46.0) | 36 (48.0) | |
| GS-US-248-0132 | |||
| Yes | 70 (70.7) | 28 (66.7) | .6337 |
| No | 29 (29.3) | 14 (33.3) | |
| SVR12 | |||
| GS-US-248-0120 | |||
| Yes | 46 (56.1) | 24 (57.1) | .9115 |
| No | 36 (43.9) | 18 (42.9) | |
| GS-US-248-0131 | |||
| Yes | 22 (25.3) | 12 (16.0) | .1478 |
| No | 65 (74.7) | 63 (84.0) | |
| GS-US-248-0132 | |||
| Yes | 44 (44.4) | 11 (26.2) | .0421 |
| No | 55 (55.6) | 31 (73.8) | |
Data are no. (%) of subjects or mean ± SD. P values ≤.05 were considered statistically significant.
Abbreviations: ALT, alanine aminotransferase; HCV, hepatitis C virus.
a Body mass index (BMI) is defined as the weight in kilograms divided by the height in square meters.