Figure 1.

POT1 mutations in familial glioma pedigrees. Individuals with glioma are shown as filled. Individuals with other cancers are shown as half filled. Disease and age in years at first diagnosis are given underneath the symbol, with current age or age at death (+) above it. Deceased individuals are designated with a slash through the symbol. Glioma type is shown (AnaO = anaplastic oligodendroglioma; Astro = astrocytoma; GBM = glioblastoma multiforme; Glioma = glioma unknown; Oligo = oligodendroglioma). Other cancers in the pedigree are shown (CoC = colon cancer; LC = lung cancer; Leuk = leukemia; Mel = melanoma). Mutations for all sequenced individuals are shown or listed as WT (wild-type).