Table 2.

Combined prediction of subsequent all-cause dementia and AD by depressive symptoms, activity variables, and social support entered into covariate-unadjusted and -adjusted models

	Model 1 (not adjusted for covariates)				Model 2 (adjusted for age, sex, education, ApoE4, MMSE, and IADL)
	all-cause dementia		AD		all-cause dementia		AD
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Depressive symptoms, activities, and social support (combined prediction)
GDS-15	1.08**	1.02 – 1.14	1.07	0.999 – 1.14	1.07*	1.01 – 1.13	1.05	0.98 – 1.13
Global activities	0.21***	0.14 – 0.31	0.19***	0.12 – 0.29	0.37***	0.25 – 0.57	0.33***	0.20 – 0.55
K-14	1.83	0.82 – 4.08	1.58	0.62 – 4.07	1.94	0.80 – 4.69	1.61	0.57 – 4.57
Depressive symptoms, activity domains, and social support factors (combined prediction)
GDS-15	1.08**	1.02 – 1.14	1.06	0.995 – 1.14	1.07*	1.00 – 1.13	1.05	0.98 – 1.14
Social engagement	0.97	0.77 – 1.21	0.94	0.71 – 1.25	0.94	0.73 – 1.21	0.91	0.67 – 1.23
Cognitive activities	0.51***	0.39 – 0.67	0.46***	0.34 – 0.64	0.70*	0.52 – 0.93	0.65*	0.45 – 0.92
Physical activities	0.49***	0.38 – 0.63	0.49***	0.36 – 0.66	0.62***	0.47 – 0.80	0.59**	0.43 – 0.82
K-14 factor 1	1.80	0.71 – 4.54	1.25	0.43 – 3.66	1.02	0.39 – 2.66	0.54	0.19 – 1.55
K-14 factor 2	1.66	0.71 – 3.90	2.28	0.79 – 6.56	2.34	0.91 – 6.02	3.57*	1.12 – 11.44
K-14 factor 3	0.76	0.47 – 1.22	0.75	0.43 – 1.33	0.92	0.56 – 1.52	1.02	0.55 – 1.87

Factor 1 = Emotional support; factor 2 = practical support; factor 3 = social integration.

^*p < 0.05

^**p < 0.01

^***p < 0.001.