Table 4.

Causal inference test (CIT) of overweight in the offspring at 16 years as a potential mediator in the association between maternal body mass index (BMI) in early pregnancy and asthma in the offspring at 16 years among mothers with BMI ≥ 18.5 (N = 2110)

Test	OR	95% CI
Maternal BMI† is associated with asthma	1.27	0.99–1.63
Maternal BMI† is associated with overweight in the child adjusted for asthma	2.50	2.09–2.98
Overweight in the child is associated with asthma adjusted for maternal BMI	1.52	0.99–2.34
Maternal BMI† is not associated with asthma adjusted for overweight in the child.	1.19	0.91–1.54

Odds ratio (OR) and 95% confidence interval (CI) are obtained from logistic regression analyses and are additionally adjusted for gender, maternal age, parental history of allergic disease, older siblings, socio-economic status and maternal smoking in pregnancy and/or at baseline.

Outcome represents 5 kg/m² increase in maternal BMI.