aExcept paroxetine.
bOr switch the SSRI to another SSRI.
cOr switch the SSRI or BUP to another SSRI or BUP.
ARI indicates aripiprazole; BUP, bupropion; DVP, divalproex; ECT, electroconvulsive therapy; LAM, lamotrigine; OLZ, olanzapine; QUE, quetiapine; RIS, risperidone; SSRI, selective serotonin reuptake inhibitor; ZIP, ziprasidone.
Reprinted with permission from Yatham LN, Kennedy SH, Parikh SV, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013. Bipolar Disord. 2013;15:1–44.