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. 2015 Jan 16;5:7820. doi: 10.1038/srep07820

Figure 5. Cytosolic DNA sensing pathway mediates both IFN-dependent and -independent antiviral responses.

Figure 5

MSCs were pretreated with JAK inhibitor Ruxolitinib (Rux) for 1 hr, then transfected with poly(dA:dT) (0.5 μg/ml), followed by MHV-68 infection (MOI 0.1). The phosphorylation of STAT1 was examined by Western blot at 2 hr post-tranfection (a). The replication of viral DNA was detected by real-time PCR at 6 hr post-infection (b). The virus titers in supernatant were determined by plaque assay at 24 hr post-infection (c). The mRNA expressions of selected ISGs were analyzed by real-time PCR at 6 hr post-tranfection (d). Data are shown as mean ± SEM of three independent experiments. **, p < 0.01; ***, p < 0.001.