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. 2014 Dec 16;2:46. doi: 10.1186/s40425-014-0046-9

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© Moertel et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CD200R antagonist blocks MDSC expansion and tumor suppressive effects. A. Murine glioma GL261 was incubated with naïve splenocytes in a trans-well plate +/- CD200R antagonist and analyzed for MDSC expansion and cytokine production. B. Naïve splenocytes were pulsed with purified CD200 +/- CD200R antagonist and analyzed for MDSC expansion and arginase-I production. Error bars are ± SEM, statistical significance was determined using an unpaired T-test, *p < 0.05, **p < 0.001.