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. 2014 Dec 21;12:109. doi: 10.1186/s12915-014-0109-x

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© Tao et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Nucleosome occupancy at the binding sites of pluripotency-related transcription factors, protein regulators and enzymes. A) The binding sites of the pluripotency transcription factors (Oct4, Sox2 and Nanog), the pluripotency regulator Smad1 in the BMB signaling pathway and the chromatin remodeler Chd7 were nucleosome depleted. B) The binding sites of self-renewal regulators (Esrrb, Tcfcp2l1 and Zfx), the PRC2 component Suz12, the coactivator p300 and Stat3 in the LIF signaling pathway were enriched on nucleosomes. C) The binding sites of the insulator-binding protein CTCF resided in the linker region with nucleosomal periodicity. D) The binding sites of factors E2F1 and c-Myc were enriched at the borders of the nucleosomes.