Skip to main content
. Author manuscript; available in PMC: 2015 Jan 16.
Published in final edited form as: Gut. 2010 Jun 28;59(8):1066–1078. doi: 10.1136/gut.2009.203893

Figure 1.

Figure 1

Increased levels of granulocyte-macrophage colony stimulating factor (GM-CSF) autoantibody (Ab) in Crohn's disease (CD) are associated with dysregulation of survival and proliferation of intestinal epithelial cells. (A) The frequency of apoptotic ileal crypt epithelial cells was determined by cleaved caspase-3 staining in healthy controls (CON) and patients with CD with high (Hi) or low (Lo) serum GM-CSF Ab. Results are expressed as mean±SEM (n=7); original magnification ×200; bar=50 μm. (B) Frequency of proliferative ileal crypt epithelial cells was determined by Ki67 staining in healthy controls and patients with CD with high or low serum GM-CSF Ab. Results are expressed as mean±SEM (n=7); original magnification ×400; bar=50 μm.