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The brain transport coefficient (Clup, μL/g s) of [3H]-diazepam was decreased in APOE4 mice. Clup was determined in APOE2, APOE3, and APOE4 mice at (A) 2, (B) 4, and (C) 12 months of age using the in situ brain perfusion technique. Data are shown as mean± standard error of the mean (s.e.m.). Statistical analyses: one-way analysis of variance (ANOVA) followed by Dunnett's multiple comparison test *P<0.05 (n=6 to 12).
