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. 2014 Oct 22;35(1):86–94. doi: 10.1038/jcbfm.2014.172

Figure 2.

Figure 2

Relative vessel density in the hippocampus was reduced in APOE4 mice. Area occupied by vessels was determined by immunohistofluorescence using anti-collagen IV antibody in 12-month-old APOE2, APOE3, and APOE4 mice. Image analyses were performed in the CA2-CA3 region of hippocampal slices located between bregma −1.46 and bregma −1.70. Data are shown as mean±standard error of the mean (s.e.m.). Statistical analyses: one-way analysis of variance (ANOVA) followed by Dunnett's multiple comparison test. *P<0.05; ***P<0.001 (n=5 to 6).