Table 1.
Effects of maropitant (M; 1 mg kg−1) versus 0.9% saline (S; 0.1 ml kg−1) administered IV 45–60 minutes before premedication with hydromorphone and acepromazine followed by propofol and inhalation anesthesia on the occurrence of vomiting and retching, gastroesophageal reflux (GER), and esophageal pH in dogs. Values are reported as mean ± SD. n = 13 per group except where noted.
| Maropitant (M)
|
Saline (S)
|
|
|---|---|---|
| I. Population Data | ||
| Gender | ||
| Males (intact/neutered) | 5 (1/4) | 3 (1/2) |
| Females (intact/spayed) | 8 (6/2) | 10 (7/3) |
| Age (years) | 2.8 ± 3.0 | 3.4 ± 3.3 |
| Body Weight (kg) | 21.5 ± 12.5 | 19.4 ± 10.7 |
| II. Study Data | ||
| Total anesthesia time (minutes) | 162 ± 41 | 146 ± 52 |
| Incidence of vomiting/retching | 0/13 dogs | 6/13 dogs* |
| Incidence of GER | 4/13 dogs | 6/13 dogs |
| Number of reflux events/case | 4 ± 5 (n = 4) | 2 ± 1 (n = 6) |
| Minimum pH during each GER | 2.1 ± 0.8 | 2.2 ± 1.0 |
| Initial esophageal pH | ||
| No GER | 6.6 ± 0.8 (n = 9) | 6.1 ± 1.5 (n = 7) |
| GER | 5.7 ± 0.9 (n = 4) | 6.5 ± 0.6 (n = 6) |
| Ending esophageal pH | ||
| No GER | 6.5 ± 0.6 (n = 9) | 6.0 ± 0.8 (n = 7) |
| GER | 4.3 ± 1.7† (n = 4) | 4.1 ± 1.5†‡ (n = 6) |
*
p = 0.015 versus Group M.
†
Group M: p = 0.004, Group S: p = 0.011 versus dogs without GER in same respective group.
‡
p = 0.004 versus initial pH in Group S with GER.