Table 3.
Specificity: percentage difference ranges in antiretroviral analytes measured when hemolysis is present %PD = ([hemolyzed value − control value]/control value) ×100.
| Analyte | N (values reported) | PD <±5 n(%) | PD ± 5–10 n(%) | PD >±10 n(%) | CPL |
|---|---|---|---|---|---|
| ATV | 5 | 5 (100%) | 0 (-) | 0 (-) | - |
| DRV | 7 | 4 (57%) | 3 (43%) | 0 (-) | - |
| EFV | 9 | 6 (67%) | 2 (22%) | 1 (11%) | 8 |
| FTC | 4 | 2 (50%) | 1 (25%) | 1 (25%) | 9 |
| LPV | 8 | 5 (63%) | 2 (25%) | 1 (12%) | 6 |
| NVP | 5 | 1 (20%) | 1 (20%) | 3 (60%) | 2, 6, 7 |
| RGV | 5 | 3 (60%) | 2 (40%) | 0 (-) | - |
| RTV | 8 | 5 (63%) | 3 (37%) | 0 (-) | - |
| TFV | 5 | 4 (80%) | 0 (0%) | 1 (20%) | 7 |
| Total | 56 | 35 (62%) | 14 (25%) | 7 (13%) | - |
%PD = ([hemolyzed value − control value]/control value) ×100.
N = Total number of reported results; n = Number in subset of results within the PD range.
ARV: Antiretroviral; ATV: Atazanavir; CPL: Clinical pharmacology laboratory; DRV: Darunavir; EFV: Efaviren; FTC: Emtricitabine; LPV: Lopinavir; NVP: Nevirapine; RGV: Raltegravir; RPD: Relative percentage difference; RTV: Ritonavir; TFV: Tenofovir.