Table 1.

Absorption and Metabolism of Vortioxetine¹⁰

Oral bioavailability	75%
Time to peak plasma concentration	7–11 hours
Metabolic pathway	CYP2D6, CYP3A4/5, CYP2C19, CYP2C9, CYP2A6, CYP2C8, and CYP2B6, with subsequent glucuronic acid conjugation
Half-life	Approximately 66 hours
Protein binding	98%
Elimination	Approximately 59% urine and 26% feces