. Author manuscript; available in PMC: 2015 Jun 1.

Published in final edited form as: Ann Surg Oncol. 2014 Feb 21;21(6):1948–1955. doi: 10.1245/s10434-014-3550-8

TABLE 1.

Site and management of local recurrences and distant metastases, and survival outcomes of 21 patients with locally recurrent osteosarcoma after limb-sparing surgery^a

		Metastases at diagnosis	Metastases at local relapse	Local relapse		Metastases after local relapse	Survival outcomes
Pati ent No.	Previous cancer	Site	Site	Site	Surgical margins	Site	Current status	OS (years)	LRFS (years)	Post- recurrence survival (years)
1		Lung (multiple) ^*		Soft tissue	≥1cm	Lung (multiple, new), Inguinal nodes ^***	DOD	2.7	1.5	1.3
2			Lung (solitary) ^*	Bone	≥1cm		NED	18.2	6.1	12.1
3			Lung (multiple) ^*	Soft tissue	<1cm		DOD	2.2	1.4	0.9
4		Lung (multiple) ^*		Soft tissue	<1cm	Lung (multiple, new), Axilla ^***	DOD	1.5	1.1	0.4
5		Lung (multiple) ^*	Lung (multiple, new), Bone (rib) ^*	Soft tissue	≥1cm	Lung (multiple, new) ^***	DOD	2.1	1	1.1
6	Ost	Bone ^*		Soft tissue	≥1cm	Lung (multiple, new), Mediastinum ^***	DOD	7.9	2.5	5.4
7			Lung (multiple) ^*	Soft tissue	No surgery		DOD	1.5	1.1	0.4
8				Bone	≥1cm		DOC^b	14	10.4	3.6
9	Rb			Bone	<1cm	Lung (multiple), Bone (spine) ^***	AWD	3.2	2	1.3
10	Ost	Lung (multiple) ^**	Lung (solitary, new) ^*	Soft tissue	≥1cm	Lung (solitary, new) ^*	AWD	4.1	2.3	1.8
11			Lung (solitary, new) ^*	Soft tissue	No surgery	Lung (multiple, new) ^***	DOD	1.9	1.4	0.5
12				Soft tissue	≥1cm		NED	11.7	4	7.7
13		Lung (solitary) ^*		Soft tissue	≥1cm	Lung (multiple, new) ^*	NED	9.3	1.3	8.0
14		Lung (multiple) ^**	Lung (multiple, new) ^***	Soft tissue	Positive		DOD	1.2	0.9	0.3
15		Bone ^*	Bone (femur, new) ^***	Soft tissue	≥1cm	Lung (multiple), Bone (rib, new) ^***	DOD	1.4	0.6	0.8
16		Lung (multiple) ^*	Lung (solitary, new) ^*	Soft tissue	Positive	Lung (solitary, new) ^***	DOD	2.2	1.3	0.9
17		Lung (solitary) ^*		Soft tissue	≥1cm	Bone (spine) ^***	AWD	3.3	2.6	0.7
18			Lung (multiple) ^*	Soft tissue	<1cm		DOD	1.2	0.9	0.3
a		Lung (multiple) ^*	Lung (multiple, new) ^***	Soft tissue	No surgery		DOD	1.7	1.2	0.5
b		Lung (multiple) ^*		Bone	No surgery	Lung (multiple, new), Bone (rib, spine) ^***	DOD	1.6	0.8	0.9
c			Lung (multiple) ^***	Soft tissue	No surgery		DOD	1.4	1.2	0.2

Patients 1–18 had local recurrence proven on histology; patients a–c (italics) were diagnosed by imaging only.

Developed acute myeloid leukemia and breast cancer.

Completely resected;

^**

Resolved with chemotherapy;

^***

Not resected.

Rb, retinoblastoma; Ost, osteosarcoma; OS, overall survival; LRFS, local recurrence-free survival; DOD, died of disease; NED, no evidence of disease; AWD, alive with disease; DOC died of other causes.