COBALT alignment of PAICS protein sequences using Genbank IDs. The Genbank IDs for the amino acid sequences are Human (Isoform 2): 119220557, Human (Isoform 1): 119220559, Mouse: 13385434, Rat: 18266726, Chinese Hamster: 354503014. CHO K1, CHO AdeD E177K, and CHO AdeD W363* are described in this report. The E177K, I237V, and W363* mutations are indicated by blue arrows. Secondary sequence is indicated above the aligned sequences. This representation of the aligned sequences was created using the Espript program (http://espript.ibcp.fr/ESPript/ESPript/).