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. 2015 Jan 8;15:7. doi: 10.1186/s12879-014-0744-4

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© Yun et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Changes of mean neutralizing antibody titers before and after vaccination. Satisfactory geometric mean titers (GMTs) were obtained after the second vaccination and before and after the third vaccinations in both vaccine groups, in both homologous and heterologous analyses. The GMTs before the third vaccination in the KD-287 group were higher than those after the second vaccination for both tested strains. After the third vaccination, the neutralizing antibody titer increased in all children, and the GMTs in both groups were higher than the respective GMTs after the second vaccination.