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. 2014 Jul 25;6(1):24–34. doi: 10.1111/jdi.12244

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© 2014 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of nitric oxide (NO) donor (NOC) treatment on Wnt5a and fibrosis factor expression of the glomerular mesangium in diabetic kidneys. Representative histology photographs of renal tissue (a) before and (b) after dissection of glomerular mesangium. NO donor treatment attenuated (c) transforming growth factor (TGF)-β1 and (d) fibronectin expression coincided with (e) reduced Wnt5a and (f) β-catenin messenger ribonucleic acid expression in the glomerular mesangium. Renal glomerular mesangium in rat kidneys were harvested by laser capture microdissection. DM, diabetic rats; NC, control group. Data were expressed as mean ± ^#P < 0.05 vs control group, ⁺P < 0.05 vs NO donor treatment group. Specimens were observed under magnification ×400.