Table 3.
Genotype and allele distribution of adiponectin gene polymorphisms in type 2 diabetes with and without retinopathy
| Model | Genotype | Cases (%) | Control (%) | OR (95% CI) | P-value |
|---|---|---|---|---|---|
| C-11377G (rs266729) n = 1039 | |||||
| Codominant | C/C | 190 (51.1) | 67 (46.2) | 1.00 (Referent) | – |
| C/G | 148 (39.8) | 60 (41.4) | 1.15 (0.76–1.73) | 0.43 | |
| G/G | 34 (9.1) | 18 (12.4) | 1.30 (0.68–2.49) | ||
| Dominant | C/C | 190 (51.1) | 67 (46.2) | 1.00 (Referent) | |
| C/G-G/G | 182 (48.9) | 78 (53.8) | 1.21 (0.82–1.78) | 0.37 | |
| Recessive | C/C-C/G | 338 (90.9) | 127 (87.6) | 1.00 (Referent) | |
| G/G | 34 (9.1) | 18 (12.4) | 1.40 (0.76–2.58) | 0.34 | |
| A-4034C (rs822394) n = 1040 | |||||
| Codominant | C/C | 288 (77.4) | 112 (77.2) | 1.00 (Referent) | – |
| A/C | 80 (21.5) | 31 (21.4) | 0.99 (0.62–1.59) | 0.95 | |
| A/A | 4 (1.1) | 2 (1.4) | 1.29 (0.22–7.40) | ||
| Dominant | C/C | 288 (77.4) | 112 (77.2) | 1.00 (Referent) | – |
| A/C-A/A | 84 (22.6) | 33 (22.8) | 1.01 (0.63–1.59) | 0.96 | |
| Recessive | C/C-A/C | 368 (98.9) | 143 (98.6) | 1.00 (Referent) | – |
| A/A | 4 (1.1) | 2 (1.4) | 1.28 (0.23–7.10) | 0.77 | |
| T45G (rs2241766) n = 1035 | |||||
| Codominant | T/T | 206 (55.5) | 82 (56.6) | 1.00 (Referent) | – |
| T/G | 140 (37.7) | 53 (36.6) | 0.95 (0.63–1.42) | 0.96 | |
| G/G | 25 (6.7) | 10 (6.8) | 1.05 (0.47–2.34) | ||
| Dominant | T/T | 206 (55.5) | 82 (56.6) | 1.00 (Referent) | – |
| T/G-G/G | 165 (44.5) | 63 (43.4) | 0.95 (0.65–1.41) | 0.91 | |
| Recessive | T/T-T/G | 346 (93.3) | 135 (93.2) | 1.00 (Referent) | – |
| G/G | 25 (6.7) | 10 (6.8) | 1.02 (0.48–2.19) | 0.94 | |
| G276T (rs1501299) n = 1040 | |||||
| Codominant | G/G | 164 (44.1) | 82 (56.5) | 1.00 (Referent) | – |
| G/T | 169 (45.4) | 55 (38) | 0.65 (0.43–0.97) | 0.02 | |
| T/T | 39 (10.5) | 8 (5.5) | 0.63 (0.27–1.43) | ||
| Dominant | G/G | 164 (44.1) | 82 (56.5) | 1.00 (Referent) | – |
| G/T-T/T | 208 (55.9) | 63 (43.5) | 0.60 (0.41–0. 89) | 0.01 | |
| Recessive | G/G-G/T | 333 (89.5) | 137 (94.5) | 1.00 (Referent) | – |
| T/T | 39 (10.5) | 8 (5.5) | 0.49 (0.22–1.09) | 0.11 | |
Genotype distributions are shown as n (%). Odds ratios (OR), 95% confidence intervals (CI), and P-values were from logistic regression analyses with codominant, dominant, recessive model controlling for family history of diabetes, insulin therapy and physical activity.