Table 2.

Multivariate analysis of prognostic factors

	All		Children		Adults
	HR	p-value	HR	p-value	HR	p-value
Gender
Male	1.00		1.00		1.00
Female	1.023 (0.693-1.511)	0.908	1.001 (0.693-1.446)	0.995	1.000 (0.790-1.231)	0.999
Age
Adult (≥ 18 yr)	1.00		-	-	-	-
Child (< 18 yr)	1.051 (0.713-1.547)	0.802	-	-	-	-
Primary site
Favorable	1.00		1.00		1.00
Non-favorable	1.262 (0.751-1.798)	0.500	1.316 (0.695-2.491)	0.399	1.181 (0.702-1.763)	0.392
Tumor size (cm)
< 5	1.00		1.00		1.00
≥ 5	1.179 (0.766-1.813)	0.454	1.540 (1.06-2.24)	0.024	1.560 (0.798-3.050)	0.193
Distant metastasis
M0	1.00		1.00		1.00
M1	1.617 (1.022-2.557)	0.040	1.851 (1.249-2.745)	0.001	1.261 (0.659-2.411)	0.484
Debulking surgery
Yes	1.00		1.00		1.00
No	1.443 (1.104-1.812)	0.012	1.811 (1.467-1.958)	0.006	1.605 (1.349-1.910)	0.003
Chemotherapy
Yes	1.00		1.00		1.00
No	1.009 (0.575-1.770)	0.975	1.243 (0.583-2.647)	0.573	1.279 (0.548-2.987)	0.570
Radiotherapy
Yes	1.00		1.00		1.00
No	1.012 (0.696-1.471)	0.951	1.078 (0.626-1.858)	0.787	0.978 (0.582-1.642)	0.932
Histopathology		0.043		0.007		0.969
RMS	1.00		1.00		1.00
EWS	1.300 (0.843-2.004)	0.236	1.756 (0.923-3.341)	0.086	0.955 (0.530-1.721)	0.879
PNET	1.562 (0.990-2.465)	0.055	2.387 (1.230-4.631)	0.010	1.023 (0.543-1.927)	0.944
DSRCT	1.560 (0.485-5.013)	0.456	2.523 (0.339-18.768)	0.366	1.063 (0.251-4.496)	0.934

HR, hazard ratio; RMS, rhabdomyosarcoma; EWS, Ewing sarcoma; PNET, primitive neuroectodermal tumor; DSCRT, desmoplastic small round-cell tumor.