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. 2015 Jan 9;8:49–67. doi: 10.2147/CEG.S70119

Table 5.

Summary of key properties of AQPs

Aquaporins Organism Main location Our findings in the GI tract Comment References
AQP0 Mammals Lens na AQP 57
AQP1 Mammals Red blood cells Reduced amounts in ileum in CD AQP 58
Kidney 59
Lung 60
Vascular endothelium This study
Brain, eye: glial cells
Neurons
AQP2 Mammals Kidney na AQP 82
Vas deferens 61
Neurons 62
AQP3 Mammals Kidney Reduced amounts in ileum in CD Aquaglyceroporin 63
Skin Water, glycerol, urea This study
Lung
Eye
Colon
AQP4 Mammals Brain, muscle, kidney, lung, stomach, small intestine AQP 64
Main AQP in the brain 65
66
Neurons
Vascular endothelium
AQP5 Mammals Salivary/lacrimal gland AQP 67
Sweat gland 68
Lung 27
Cornea
AQP6 Mammals Kidney na AQP 7
Anion channel
AQP7 Mammals Adipose tissue Reduced amounts Aquaglyceroporin 69
Kidney in ileum and Water, glycerol, urea, arsenite This study
Testis colon in UC
AQP8 Mammals Testis, kidney, liver, pancreas, small intestine, colon Reduced amounts in ileum and colon in UC AQP 70
This study
AQP9 Mammals Liver, leukocytes, brain, testis Aquaglyceroporin 71
Water, glycerol, urea, arsenite
AQP10 Mammals Small intestine na Aquaglyceroporin 72
Kidney Water, glycerol, urea 6
AQP11 Mammals Kidney ER na Super-AQP 73
Divergent NPA motif, sign cysteine
AQP12 Mammals Pancreas na Super-AQP 74
Divergent NPA motif, sign cysteine
AQPZ E. coli, Mycobacterium abscessus* na na AQP 75
This study*
GlpF E. coli, Haemophilus influenzae, Streptococcus pyogenes* na na Aquaglyceroporin 75
76
This study*
AQY1/2 Yeast na na AQP 77
78
GLPY1/2 Yeast na na Aquaglyceroporin 79
PIPs/TIPs/ Plants na na AQP 80
NIPs/SIPs 81

Note: – indicates not detected above threshold in the gut.

Abbreviations: AQP, aquaporin; AQPZ, aquaporin-related pore; na, not applicable; E. coli, Escherichia coli; ER, endoplasmic reticulum; glpF, glycerol facilitator; GI, gastrointestinal; NPA, asparagine-proline-alanine; CD, Crohn’s disease; NIPs, nodulin 26-like intrinsic membrane proteins; PIPs, plasma membrane intrinsic proteins; SIPs, small basic intrinsic proteins; TIPs, tonoplast intrinsic proteins; UC, ulcerative colitis; AQY1/2, yeast aquaporin; GLPY1/2, yeast glycerol facilitation-like protein.