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. 2015 Jan 9;10:485–502. doi: 10.2147/IJN.S72730

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© 2015 Kim et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Masson’s trichrome-stained histological section after implantation.

Notes: Representative histological sections show cross sections of the defect center after (A) 1 week, (B) 2 weeks, (C) 4 weeks, and (D) 8 weeks. Note the presence of blood clots (empty red arrows), inflammatory cells (thin yellow arrows), osteoblasts (arrowheads), and remaining scaffold (asterisks). Original magnification 100×.

Abbreviations: PCL, poly(ε-caprolactone); SF, silk fibroin; NB, new bone; BV, blood vessel; CT, connective tissue.