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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Nov 24;25(2):292–296. doi: 10.1016/j.bmcl.2014.11.047

Table 1.

Data for reference compounds NT, 4, 5, 6 and test compounds 9, 14b and 16b at the rNTSl and rNTS2 receptors

FLIPR Assay Binding Assaya
NTS2 NTS1 NTS2
# EC50b EEmaxc IC50 Ki Ki
NT >100 μM 42±4 1.7±0.3 21±9
4 18±5 100±5 2.0±0.4 7.0±2.3
5 d 28±4 16±3 >25 μM 33±5
6 d 12±6 7±2 >10 μM 153±10
9 14±4 18±3 >25 μM 88±27
14b >10 μM 1067±187 >25 μM 474±112
16b 145±10 26±3 >25 μM 959±119
a

[125I]NT

b

EC50, IC50 and Ki values are nM±SEM

c

Emax value is % of 4

d

Data taken from reference 30.